N-Phosphoroamino Acids and Peptides

Abstract

A method for the synthesis of N-phosphoroamino acids and peptides is described. Di-p-nitrobenzylphosphorochloridate or di-p-iodobenzylphosphorochloridate was coupled with esters of amino acids or peptides; this was followed by removal of the p-nitrobenzyl and p-iodobenzyl groups through catalytic hydrogenation in alcoholic alkaline medium. © 1955, American Chemical Society. All rights reserved

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