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Lipophilicity and Chromatographic Behaviour of Benzoic Acid Derivatives
Authors
M. Pagou Koutselinis, A.
Publication date
1 January 1993
Publisher
Abstract
The Rm values of 32 compounds, derivatives of benzoic acid, were determined by reversed-phase thin layer chromatography (RP-TLC). The logarithm of the capacity factor, log k1, of the same compounds was studied with reversed-phase high performance liquid chromatography (RP-HPLC). The lipophilicity was calculated according to the fragmental methods of Rekker and of Leo-Hansch and was compared with the experimental values of Rm and the log k1. The comparison shows that the Rekker method gives a better description of lipophilicity than that of the Leo-Hansch method. © 1993, The Pharmaceutical Society of Japan. All rights reserved
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Last time updated on 10/02/2023