CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Predictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial
Authors
M.S. van der Heijden Powles, T. Petrylak, D. de Wit, R. Necchi, A. Sternberg, C.N. Matsubara, N. Nishiyama, H. Castellano, D. Hussain, S.A. Bamias, A. Gakis, G. Lee, J.-L. Tagawa, S.T. Vaishampayan, U. Aragon-Ching, J.B. Eigl, B.J. Hozak, R.R. Rasmussen, E.R. Xia, M.S. Rhodes, R. Wijayawardana, S. Bell-McGuinn, K.M. Aggarwal, A. Drakaki, A.
Publication date
1 January 2022
Publisher
Abstract
The RANGE study (NCT02426125) evaluated ramucirumab (an anti-VEGFR2 monoclonal antibody) in patients with platinum-refractory advanced urothelial carcinoma (UC). Here, we use programmed cell death-ligand 1 (PD-L1) immunohistochemistry (IHC) and transcriptome analysis to evaluate the association of immune and angiogenesis pathways, and molecular subtypes, with overall survival (OS) in UC. Higher PD-L1 IHC and immune pathway scores, but not angiogenesis scores, are associated with greater ramucirumab OS benefit. Additionally, Basal subtypes, which have higher PD-L1 IHC and immune/angiogenesis pathway scores, show greater ramucirumab OS benefit compared to Luminal subtypes, which have relatively lower scores. Multivariable analysis suggests patients from East Asia as having lower immune/angiogenesis signature scores, which correlates with decreased ramucirumab OS benefit. Our data highlight the utility of multiple biomarkers including PD-L1, molecular subtype, and immune phenotype in identifying patients with UC who might derive the greatest benefit from treatment with ramucirumab. © 2022, The Author(s)
Similar works
Full text
Available Versions
Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:lib.uoa.gr:uoadl:3219241
Last time updated on 10/02/2023