CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project
Authors
M. Bassetti Giacobbe, D.R. Vena, A. Trucchi, C. Ansaldi, F. Antonelli, M. Adamkova, V. Alicino, C. Almyroudi, M.-P. Atchade, E. Azzini, A.M. Carannante, N. Carnelutti, A. Corcione, S. Cortegiani, A. Dimopoulos, G. Dubler, S. García-Garmendia, J.L. Girardis, M. Cornely, O.A. Ianniruberto, S. Kullberg, B.J. Lagrou, K. Le Bihan, C. Luzzati, R. Malbrain, M.L.N.G. Merelli, M. Marques, A.J. Martin-Loeches, I. Mesini, A. Paiva, J.-A. Peghin, M. Raineri, S.M. Rautemaa-Richardson, R. Schouten, J. Brugnaro, P. Spapen, H. Tasioudis, P. Timsit, J.-F. Tisa, V. Tumbarello, M. Van Den Berg, C.H.S.B. Veber, B. Venditti, M. Voiriot, G. Wauters, J. Montravers, P.
Publication date
1 January 2019
Publisher
Abstract
Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions. © 2019 The Author(s)
Similar works
Full text
Available Versions
Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:lib.uoa.gr:uoadl:3105923
Last time updated on 10/02/2023