Coronavirus disease 2019 has developed as a pandemic. Immunization with
the introduction of vaccines against COVID-19 seems be the only way to
end this pandemic. We report on a case of a kidney donor, who developed
minimal change disease (MCD) within 4 days post-vaccination with the
SARS-CoV-2 BNT162b2 mRNA vaccine (Pfizer/BioNTech). She donated her
kidney to her husband 4 years ago. After receiving the 1st vaccine dose,
she presented with nephrotic syndrome, with complete remission 5 days
later. She proceeded with the second dose of the BNT162b2 vaccine at the
appointed time. Two days later, she presented with a relapse of
full-blown nephrotic syndrome with preserved renal function. We
performed an ultrasound-guided percutaneous kidney biopsy and the final
diagnosis was consistent with minimal change disease. Oral prednisolone
was promptly initiated at a dosage of 1 mg/kg daily and complete
remission was achieved 10 days later. More data about this rare
appearance of de novo glomerular diseases after SARS-CoV-2 vaccination
are emerging and should be interpreted rigorously
