An unusual multiply resistant corynebacterium was isolated from the urine of a comatose patient. This organism was resistant to sulphafurazole, trimethoprim, nalidixic acid, cefazolin, nitrofurantoin, clindamycin, erythromycin, oxacillin, penicillin, gentamicin, amikacin, cinoxacin, ceftazidime and ceftazidime, but was susceptible to ciprofloxacin, ofloxacin, norfloxacin, vancomycin and fucidin. It was identified as the first reported isolate in South Africa of corynebacterium group D2, an organism recently implicated in alkaline-encrusted cystitis and urinary tract infection. We discuss the case history of the patient and review the literature