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Oxidative stress in ageing and disease development studied by FT-IR spectroscopy
Authors
J. Anastassopoulou Kyriakidou, M. Kyriazis, S. Mavrogenis, A.F. Mamareli, V. Mamarelis, I. Petra, M. Malesiou, E. Kotoulas, C. Kolovou, P. Koutoulakis, E. Markouizou, A. Theophanides, T.
Publication date
1 January 2018
Publisher
Abstract
FT-IR spectroscopy was used to investigate the effect of oxidative stress and to approach the mechanism on cancer bone demineralization, aortic valve mineralization and heterotopic ossification on disease development. The FT-IR spectra obtained from paediatric, adult bone and ex vivo irradiated adult healthy bone with a dose of 20 Gy were compared with those of healthy bone. The increase of band intensity changes of vasCH2 vsCH2 in the region 3000–2850 cm−1 depended on aging, the disease progression and the dose of irradiation. The bands at 3080 cm−1 and 1744 cm−1, which originate from olefinic terminal bond (v = CH) and ester carbonyl group (vRO–C[dbnd]O), respectively, indicate the influence of oxidative stress on lipid degradation and peroxidation, respectively. The new bands at about 1690 cm−1 and 1516 cm−1 denote the presence of β-sheet conformation of the proteins due to the diseases, confirming the increasing amount of lipophilic environment and fibril formation. Comparison of the FT-IR spectra of calcified aortic valve and hip heterotopic ossification with that of normal bones showed that in the bone-like formation the peroxide anion free radicals play an important role in the disease. © 2017 Elsevier B.V
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Last time updated on 10/02/2023