Early life exposure to endocrine-disrupting chemicals (EDCs) is
considered a potential risk factor for aberrant brain development and
the emergence of behavioral deficits. The purpose of this review is to
summarize the toxic effects of bisphenol-A (BPA) and phthalate exposure
during pre-, -post-or perinatal life on different types of behaviour in
male and female rodents. Despite results not being always consistent,
most probably due to methodological issues, it is highly probable that
early life exposure to BPA or/and phthalates, affects various aspects of
behaviour in the offspring. Adverse effects include: Increased levels of
anxiety, altered exploratory behaviour, reduced social interaction or
increased aggression and deficits in spatial or recognition learning and
memory. These effects have been observed with a wide range of doses, in
some cases even below the currently employed Tolerable Daily Intake dose
for either BPA or phthalates. (c) 2021 Elsevier Ltd. All rights
reserved