Introduction/Objectives: Periodontitis comprises of a wide range of
inflammatory conditions of the gums leading to soft tissue damage and
attachment loss. The initiation of periodontitis constitutes a rather
complex disease pathogenesis which is based on pathogenic shifts of the
oral microbiota combined with the host-microbiome interactions. The
severity of the periodontitis is multifactorial depending on genetic,
environmental, as well as host immunity factors. Data and sources: To
make an inclusive analysis on the periodontitis therapeutics, reading of
the recent relevant literature was carried out using the MEDLINE/PubMed
database, Google Scholar and the NIH public online database for clinical
trials (http://www.clinicaltrials.gov). Conclusions: Tackling the
inflammation associated periodontal defects can be succeeded with
conventional therapy or resective and regenerative treatment. To date,
the mechanical removal of the supragingival and subgingival biofilm is
considered the “gold standard” of periodontal therapy in combination
with the use of antibacterial compounds. The antimicrobial resistance
phenomenon tends to turn all the currently applied antibacterials into
“endangered species”. Ongoing efforts through the conduct of
clinical trials should be focused on understanding the advantages of
modern approaches in comparison to traditional therapies