Nanomedicine is based on the fact that biological molecules behave
similarly to nanomolecules, which have a size of less than 100 nm, and
is now affecting most areas of orthopedics. In orthopedic oncology, most
of the in vitro and in vivo studies have used osteosarcoma or Ewing
sarcoma cell lineages. In this article, tumor imaging and treatment
nanotechnology applications, including nanostructure delivery of
chemotherapeutic agents, gene therapy, and the role of
nano-selenium-coated implants, are outlined. Finally, the potential role
of nanotechnology in addressing the challenges of drug and radiotherapy
resistance is discussed
