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PIFA-mediated synthesis of novel pyrazoloquinolin-4-ones as potential ligands for the estrogen receptor
Authors
M.S. Christodoulou Kasiotis, K.M. Fokialakis, N. Tellitu, I. Haroutounian, S.A.
Publication date
1 January 2008
Publisher
Abstract
A facile and efficient preparation of pyrazoloquinolin-4-ones, as potential ligands for the estrogen receptor, via a PIFA [phenyliodine(III)bis(trifluoroacetate)] promoted cyclization reaction with overall yields up to 29% over six steps is described. The employed strategy, based on an electrophilic amidation reaction as the key step of the synthesis, allows the generation of a diverse array of derivatives. © 2008 Elsevier Ltd. All rights reserved
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Last time updated on 10/02/2023