The purpose of this study was to describe the diagnosis, treatment, and
follow-up of patients with concomitant primary ovarian and endometrial
carcinomas. From a database of 339 endometrial and ovarian carcinomas, 9
patients with synchronous primary ovarian and endometrial malignancies
were studied. Four patients (44%) had endometroid carcinoma in the
ovaries and the endometrium, and 5 (56%) had differing histology. The
mean age of the 9 patients was 55.4 +/- 5.1 years. Abnormal uterine
bleeding was the main symptom in 4 patients (44.4%), whereas three
(33.3%) presented with pelvic pain and 2 (22.3%) with ascites. All 9
women underwent total abdominal hysterectomy with bilateral
salpingo-oophorectomy. In 4 cases, omentectomy and lymphadenectomy was
also carried out. Peritoneal washing showed positive results for
malignant cells in 4 cases. In 8 patients, chemotherapy was administered
after the operation. All patients have remained alive without evidence
of recurrence 5-8 years after the operation (100% 5-year survival
rate). It is concluded that the frequency of synchronous primary ovarian
and endometrial carcinomas is 2.6%, and the prognosis following
appropriate treatment is favorable
