A study on some effects of the extracts of unripe paw-paw (Carica papaya linn) on wound healing in Wistar rats ( Rattus novegicus)

Abstract

Background: Wound healing is the process of repair that follows injury to the skin and soft tissues. Attempt at finding a perfect wound-healing agent has a long history. The emphasis was on finding an agent that is affordable, effective and with minimal side effects. Aim: To confirm some effects of the medicinal properties of the extracts of unripe pawpaw as a wound healing agent and it's reported antimicrobial activities. Methods: Twenty adult male Wistar rats of average weight 150-200 g were used for this study. They were split into two groups: Normal saline (controls) and paw-paw (Carica papaya linn) extract experimental groups. Ethical clearance was obtained from relevant institutions and departments for this study. Each animal was weighed and anaesthetized using combinations of ketamine (0.1ml/kg) and diazepam (0.1ml/kg). Each rat was shaved on the right dorso-lateral aspect of the thoracic wall and wiped with 70% methylated spirit soaked in gauze. A 2 cm by 2 cm square skin area was measured    and    excised,   and   wounds   were dressed with paw-paw extracts in experimental group and normal saline in control group. Results: The results revealed significant wound contraction (