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Design, synthesis, and evaluation of the antiproliferative activity of a series of novel fused xanthenone aminoderivatives in human breast cancer cells
Authors
V. Giannouli Kostakis, I.K. Pouli, N. Marakos, P. Kousidou, O.Ch. Tzanakakis, G.N. Karamanos, N.K.
Publication date
1 January 2007
Publisher
Abstract
Derivatives of two novel, structurally related heterocyclic ring systems, xantheno[3,4-d]imidazole and chromeno[4,3,2-c,d]imidazo[4,5-f]indazole, bearing aminoalkyl side chains, have been synthesized, and their antiproliferative activity has been studied against the aggressive human breast MDA-MB-231 cell line. The pyrazole-fused analogue 27a possesses a pronounced antiproliferative effect on the tested cell line, evident at 1 μM, and achieves an IC 50 of 6.5 μM. © 2007 American Chemical Society
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Last time updated on 10/02/2023