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Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands
Authors
F. Naoum Kasiotis, K.M. Magiatis, P. Haroutounian, S.A.
Publication date
1 January 2007
Publisher
Abstract
Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities. © 2007 by MDPI
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Last time updated on 10/02/2023