A patient who survived for 21 years since initial discovery of
glucagonoma with concurrent liver metastases is described. Psychiatric
symptoms, weight loss, necrolytic migratory erythema, diarrhea, and dia
betes mellitus developed gradually after diagnosis of the tumor. No
specific treatment was administered. The longevity of this patient may
be related to the slow tumor growth expressed histologically by ischemic
necrosis of the malignant cells and in imaging by extensive tumor
calcifications, a very rare finding in this type of the tumor
