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Biomonitoring of bisphenol A in hair of greek population
Authors
M.N. Tzatzarakis Vakonaki, E. Kavvalakis, M.P. Barmpas, M. Kokkinakis, E.N. Xenos, K. Tsatsakis, A.M.
Publication date
1 January 2015
Publisher
Abstract
Objective: Bisphenol A (BPA) is considered as an endocrine-disruptor in which humans are exposed daily mainly by food-contact products, toys, recycled paper and drinking containers. In this study, we validated a method for the isolation and the detection of BPA in human head hair samples and estimated the burden of BPA in hair of Greek population. Methods: Hair samples were collected from 69 volunteers. The isolation of the BPA was performed by solid-liquid extraction with methanol and its determination by a liquid chromatography-mass spectrometry technique. Results: The limits of quantification (LOQ=9.7pgmg-1), the accuracy (92.6%), the precision (inter 15.3%, intra 13.0%), the ion suppression (<8.1%) and the recovery (88.3%) of the method were found satisfactory. Differences in the detection rates of the positive samples as well in detected levels of BPA between rural and urban population were observed. The 41.2% of the samples collected from urban population were positive whereas the positive samples from rural population were 14.8% (p=0.025). The mean concentration of the positive samples for the urban population was 64.1pgmg-1 (17.7-192.8pgmg-1), for the rural population 40.3pgmg-1 (13.1-72.8pgmg-1) and for the children 37.9pgmg-1 (13.1-72.8pgmg-1). Significant statistical differences (p=0.021) were observed though between urban and rural population only when negative samples were replaced with LOD/2 values. Conclusion: The proposed method was successfully applied for the determination of BPA in hair for the estimation of the population burden to BPA. © 2014 Elsevier Ltd
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Last time updated on 10/02/2023