Prophylactic cranial irradiation (PCI) is known to improve survival to a
significant degree in Small Cell Lung Cancer (SCLC) patients. The aim of
our study is to investigate changes in structural connectivity between
healthy-volunteers and patients with SCLC, before and after PCI
treatment. In this preliminary study we use diffusion tensor imaging
(DTI) to identify changes in white matter structure in patient group pre
radiotherapy to control group. The results have showed alterations in
white matter structure. In the patient group lower fractional anisotropy
(FA) and higher eigenvalues in white matter regions are observed
compared to the control group. The results presented herein are subject
to further investigation with larger patient and control groups
