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Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells
Authors
I.K. Kostakis Pouli, N. Marakos, P. Kousidou, O.Ch. Roussidis, A. Tzanakakis, G.N. Karamanos, N.K.
Publication date
1 January 2008
Publisher
Abstract
A series of novel aminosubstituted xantheno[1,2-d]imidazole derivatives have been designed and synthesized and their antiproliferative activity has been evaluated against human breast MDA-MB-231 cell line. Among the tested compounds those bearing two basic side chains at 2- and 5-positions exhibited a strong dose-dependent antiproliferative activity. Increase of the size and basicity of the N-alkyl substituent resulted in amplification of the inhibitory activity. © 2007 Elsevier Ltd. All rights reserved
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Last time updated on 10/02/2023