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Oral L-arginine supplementation and faecal calprotectin levels in very low birth weight neonates
Authors
E. Polycarpou Zachaki, S. Papaevangelou, V. Tsolia, M. Kyriacou, A. Kostalos, C. Kafetzis, D.
Publication date
1 January 2013
Publisher
Abstract
Objective:The objective of this study is to determine the potential effect of oral L-arginine supplementation on intestinal inflammation in very low birth weight (VLBW) neonates, as estimated by faecal calprotectin levels.Study Design:The study enrolled 83 VLBW neonates with birth weight ≤1500 g and gestational age ≤34 weeks. In this double-blind study, 40 neonates received daily oral L-arginine supplementation of 1.5 mmol kg -1 per day between the 3rd and 28th day of life, and 43 neonates placebo. Stool samples were collected on days 3, 14 and 28, and calprotectin was measured by enzyme-linked immunosorbent assay.Result:Calprotectin values significantly decreased over time in both groups (P=0.032). No difference in faecal calprotectin values was recorded between neonates receiving arginine supplementation and neonates receiving placebo at days 3, 14 and 28.Conclusion:Faecal calprotectin values decrease with increasing postnatal age in VLBW infants, but this is not related to arginine supplementation. © 2013 Nature America, Inc. All rights reserved
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Last time updated on 10/02/2023