COVID-19 is disease caused by SARS-CoV-2 virus which was first discovered in Wuhan, China on the end of 2019. The COVID-19 pandemic generates many sufferers to experience symptoms of depression. Natural plant has been used for a long time for various ailments, including depression. This literature review aims to describe various types of plants and their mechanisms that can be used to help deal with symptoms of depression during the COVID-19 pandemic. This article was compiled by conducting a literature search using the keywords “covid-19”, “depression”, and “natural products” on PubMed, Scopus and Cochrane Library engine searching and followed the inclusion criteria, namely, the maximum literature publications from the last 10 y in English and discuss natural products that can be used to help overcome depression during the covid-19 pandemic. We found that thirteen medicinal plants are noteworthy to be considered as antidepressant drug candidates. The medicinal compounds need to be developed furthermore in the future since Covid-19 pandemic is not over yet. These plants have established the molecular mechanism to remedies depression and hopefully can be alternatives medicine to treat depression that have mild side effects compared to synthetic drugs
