Geothermal resources are one of the most valuable renewable energy sources because of their stability, reliability, cleanliness, safety and abundant reserves. Efficient and economical remote sensing and GIS (Geographic Information System) technology has high practical value in geothermal resources exploration. However, different study areas have different geothermal formation mechanisms. In the process of establishing the model, which factors are used for modeling and how to quantify the factors reasonably are still problems to be analyzed and studied. Taking Hangjiahu Plain of Zhejiang Province as an example, based on geothermal exploration and remote sensing interpretation data, the correlation between the existing geothermal hot spots and geothermal related factors was evaluated in this paper, such as lithology, fault zone distance, surface water system and its distance, seismic point distance, magmatic rock and volcanic rock distance, surface water, farmland, woodland temperature and so on. The relationship between geothermal potential and distribution characteristics of surface thermal environment, fault activity, surface water system and other factors was explored. AHP (Analytic Hierarchy Process) and BP (Back Propagation) neural network were used for establishing geothermal potential target evaluation models. The potential geothermal areas of Hangjiahu Plain were divided into five grades using geothermal exploration model, and most geothermal drilling sites were distributed in extremely high potential areas and high potential areas. The results show that it is feasible to analyze geothermal potential targets using remote sensing interpretation data and geographic information system analysis databased on analytic hierarchy process analytic hierarchy process and back propagation neural network, and the distribution characteristics of surface thermal environment, fault activity, surface water system and other related factors are also related to geothermal distribution. The prediction results of the model coincide with the existing geothermal drilling sites, which provides a new idea for geothermal exploration