Leyder, Tanguy

Michaux, Catherine

Mignon, Julien

English

Cancer is a worldwide human disease of great concern, in which proteins are known to be highly involved, especially the group of intrinsically disordered proteins (IDPs). Due to their disorder-associated properties and floppy structure, IDPs remain difficult to target, requiring the design of new anticancer strategies. In that context, the zinc finger protein DPF3 has been identified as an amyloidogenic IDP involved in numerous cancer types, such as breast, brain, bone marrow, kidney, and lung cancer. Therefore, investigating DPF3 druggability will help to elucidate its oncogenic mechanisms, as well as to pave the way towards efficient IDP-specific therapies

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The intrinsically disordered DPF3 zinc finger protein:a promising new target in cancer therapy

https://pure.unamur.be/ws/files/72447628/jcancerbiolmignonj.pdf

The intrinsically disordered DPF3 zinc finger protein: a promising new target in cancer therapy

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Repository of the University of Namur