The fusion program in the Karlsruhe Institute of Technology (KIT) leads the R&D of the DEMO helium-cooled pebble bed (HCPB) breeding blanket within the work package breeding blanket (WPBB) of the Eurofusion Consortium in the European Union (EU). A new design of the HCPB breeder zone, with a layout inspired by a nuclear reactor fuel rod arrangement, was developed recently and called the fuel-breeder pin concept. In addition, a mock-up (MU) of this fuel-breeder pin was designed and manufactured at KIT in order to test and validate its thermal–hydraulic performance. This paper reports on the results of the first experimental campaign dedicated to the fuel-breeder pin MU testing that was performed in the Helium Loop Karlsruhe (HELOKA) facility. The paper presents: (i) the integration of the fuel-breeder pin MU into the HELOKA loop including considerations of the experimental set-up, (ii) an overview of the plan for the experimental campaigns, and (iii) a discussion of the experimental results with a focus on aspects relevant for the validation of the thermal–hydraulic design of the HCPB breeder zone