CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Impairment of episodic memory in genetic frontotemporal dementia: A genfi study
Authors
C Andersson
A Antonell
+99 more
S Archetti
A Arighi
M Balasa
M Barandiaran
N Bargallo
R Bartha
B Bender
IL Ber
S Black
M Bocchetta
S Borrego-Ecija
B Borroni
A Bouzigues
J Bras
CR Butler
D Cash
R Convery
T Cope
A Danek
S Ducharme
A Díez
C Fenoglio
E Finger
NC Fox
M Freedman
G Fumagalli
A Gabilondo
D Galimberti
R Gasparotti
S Gazzina
GENFI Genetic FTD Initiative
A Gerhard
A Gorostidi
C Graff
CV Greaves
R Guerreiro
C Heller
B Indakoetxea
V Jelic
LC Jiskoot
HO Karnarth
R Keren
R Laforce
J Levin
A Lladó
M Masellis
S Mead
AD Medonça
L Meeter
RV Minkelen
S Mitchell
K Moore
F Moreno
A Nelson
J Nicholas
J Olives
M Otto
J Pan-Man
JM Papma
F Pasquier
G Peakman
YAL Pijnenburg
JM Poos
E Premi
R Rademakers
T Rittman
E Rogaeva
JD Rohrer
MN Rossor
JB Rowe
LL Russell
R Sanchez-Valle
I Santana
E Scarpini
H Seelaar
R Shafei
C Shoe-Smith
S Sorbi
IJ Swift
M Synofzik
F Tagliavini
M Tainta
D Tang-Wai
C Tartaglia
DL Thomas
H Thon-Berg
C Timberlake
E Todd
E van den Berg
EL van der Ende
JC van Swieten
R Vandenberghe
J Vil-Lanua
JD Warren
C Wilke
I Woollacott
H Zetterberg
M Zulaica
L Öijerstedt
Publication date
13 May 2021
Publisher
'Wiley'
Doi
Abstract
Supporting Information: dad212185-sup-0001-Appendix.docx (369.8 KB) available online at https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12185#support-information-sectionCopyright © 2021 The Authors. Introduction: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progranulin [GRN], and 73 microtubule-associated protein tau [MAPT]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel-based morphometry to investigate the underlying neural substrates of the FCSRT. Results: All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion: The FCSRT detects presymptomatic deficits in C9orf72- and MAPT-associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.The Dementia Research Centre is supported by Alzheimer's Research UK, Alzheimer's Society, Brain Research UK, and The Wolfson Foundation. This work was supported by the NIHR UCL/H Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility, and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK. J. D. Rohrer is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). This work was also supported by the MRC UK GENFI grant (MR/M023664/1); the Bluefield Project; the JPND GENFI-PROX grant (2019-02248); the Dioraphte Foundation (grant numbers 09-02-00); the Association for Frontotemporal Dementias Research Grant 2009; The Netherlands Organization for Scientific Research (NWO; grant HCMI 056-13-018); ZonMw Memorabel (Deltaplan Dementie, project numbers 733 050 103 and 733 050 813); JPND PreFrontAls consortium (project number 733051042). J. M. Poos is supported by a Fellowship award from Alzheimer Nederland (WE.15-2019.02). This work was conducted using the MRC Dementias Platform UK (MR/L023784/1 and MR/009076/1). Several authors of this publication are members of the European Reference Network for Rare Neurological Diseases - Project ID No 739510
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Sustaining member
Brunel University Research Archive
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:bura.brunel.ac.uk:2438/257...
Last time updated on 12/01/2023