The CuZn superoxide dismutase (CuZnSOD) protein expression in liver of Wistar male rats exposed to acute (immobilization or cold), chronic (isolation, crowding or daily swimming) or combined stressors was followed by Western immunoblotting. Relatively increase levels of CuZnSOD in acute stress conditions are required to remove high level of ROS in order to protect against ROS damage in liver. The moderate SOD up-regulation under chronic and combined stress may lead to inefficient ROS defense and increased oxidative damage of liver under the stress conditions In that view, special care should be played to development of antioxidant therapeutics for antagonizing stress induced redox disbalances in cells.Physical chemistry 2006 : 8th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 26-29 September 200
