Depolymerisation of F-actin to G-actin and its repolymerisation in the presence of analogs of adenosine triphosphate

Abstract

A number of ATP analogs were tested for their ability to depolymerize F-actin and interact with it. It was found that those analogues which are hydrolysable are incorporated into the F-actin polymer whereas the non-hydrolysable ones are displaced from the nucleotide binding site during the polymerization proces