Leishmaniasis is a protozoan infection due to organisms of the genus Leishmania. The differential diagnosis of cutane-ous leishmaniasis includes arthropod bites, basal cell carcinoma (BCC) and other malignancies. BCC is the most com-mon form of skin cancer. We present a case of cutaneous leishmaniasis resistant to standard intralesional glucantime injection in an immunocompromised patient, which was proved to be BCC after surgical excision