Background: Associations between the combined effect of physical activity and screen based activities on health related quality of life remain largely undetermined. Methods: During 2008–2010, cross-sectional data for self-reported health related quality of life, physical activity, and screen-time were collected for 3796 Australian adults. Logistic regression was conducted to examine associations for six combinations of physical activity (none, insufficient, and sufficient), and screen-time (low and high) on health related quality of life