Let F be a field and E an extension of F with [E:F]=d where the characteristic of F is zero or prime to d. We assume μd2⊂F where μd2 are the d2th roots of unity. This thesis studies the problem of determining the cohomological kernel Hn(E/F):=ker(Hn(F,μd)→Hn(E,μd)) (Galois cohomology with coefficients in the dth roots of unity) when the Galois closure of E is a semi-direct product of cyclic groups. The main result is a six-term exact sequence determining the kernel as the middle map and is based on tools of Positelski \cite{Positselski}. When n=2 this kernel is the relative Brauer group Br(E/F), the classes of central simple algebras in the Brauer group of F split in the field E. In the case where E has degree d and the Galois closure of E, \tE has Galois group {\rm Gal}(\tE/F) a dihedral group of degree 2d, then work of Rowen and Saltman (1982) \cite{RowenSaltman} shows every division algebra D of index d split by E is cyclic over F (that is, D has a cyclic maximal subfield.) This work, along with work of Aravire and Jacob (2008, 2018) \cite{AJ08} \cite{AJ18} which calculated the groups Hpmn(E/F) in the case of semi-direct products of cyclic groups in characteristic p, provides motivation for this work