Serum lipids abnormalities and psoriasis

Abstract

Context: Psoriasis is a chronic proliferative inflammatory skin disease with unknown etiology. The loss of scale from the surface observed in the course of psoriasis may be related to lipid disorders in epidermis and in serum. Moreover a predisposition to occlusive vascular disease and increased cardiovascular morbidity has been reported. Aims: In this study, the serum lipid levels of psoriatic patients were investigated to detect any relation in this respect. Materials and Methods: 60 psoriatic and 120 nonpsoriatic individuals were included in this case control study and were analogized for sex, age and body mass indices. Total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were measured. Statistical Analysis Used: Collected data were analyzed by statistical tests of Chi square, Mann Whitney and Kruskal Wallis applying SPSS software. Results: Total cholesterol, triglyceride and LDL-C were found to be significantly higher than in normal control group ( P < 0.05). No significant statistical difference was observed between HDL level of the two groups. Conclusions: We concluded that psoriatic patients should be evaluated for hyperlipidemia and obstructive vascular diseases. Administrating lipid-lowering medicines for patients particularly cases with severe disease may be beneficial prognosis