The Overdose Entoxication of Alprazolam, Purposing Suicide

Abstract

Alprazolam (Xanax) is a triazolobenzodiazepine derivative, mainly usedas an anxiolytic and antidepressant, but also efficient in the treatment ofagoraphobia, panic attacks and panic disorders. Daily doses of 0.75–4 mgare effective for generalized anxiety, while daily doses of 6–9 mg have beenused for phobic and panic disorders. High-dose benzodiazepines classicallyinduce bradicardia in heart. And also, benzodiazepines are known to reducemyocardial contractility and increase myocardial blood flow: a reducedmyocardial function may compromise the hemodynamic status even further.In this study we tried to investigate the central nervous system and cardiaceffects that has been seen in high doses alprazolam intoxication cases withthe help of the literatures. Here in, we presented three cases of high dosesalprazolam intoxication