Cold, S.

Eastell, R.

Folkestad, L.

Frölich, J.

Gossiel, F.

Hill, T.

Mathers, J.C.

Perri, G.

Walsh, J.

Winther, K.

Mathers, J. C.

Frolich, J.

Syddansk Universitets Forskerportal

Effect of selenium supplementation on biomarkers of bone turnover

White Rose Research Online

This is a repository copy of Effect of selenium supplementation on biomarkers of bone turnover.White Rose Research Online URL for this paper:https://eprints.whiterose.ac.uk/195243/Version: Published VersionProceedings Paper:Perri, G., Hill, T., Mathers, J.C. et al. (7 more authors) (2021) Effect of selenium supplementation on biomarkers of bone turnover. In: Proceedings of the Nutrition Society. Irish Section Conference, 22-24 Jun 2021, Online. Cambridge University Press (CUP) , e110. https://doi.org/10.1017/s0029665121002330© The Authors 2021. Reproduced in accordance with the publisher's self-archiving policy.eprints@whiterose.ac.ukhttps://eprints.whiterose.ac.uk/Reuse Items deposited in White Rose Research Online are protected by copyright, with all rights reserved unless indicated otherwise. They may be downloaded and/or printed for private study, or other acts as permitted by national copyright laws. The publisher or other rights holders may allow further reproduction and re-use of the full text version. This is indicated by the licence information on the White Rose Research Online record for the item. Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. Irish Section Conference, 22–24 June 2021, Nutrition, health and ageing — translating science into practice – Part AEffect of selenium supplementation on biomarkers of bone turnoverG. Perri1, T. Hill1, J.C. Mathers1, J. Walsh2, F. Gossiel2, K. Winther3,4,5, J. Frölich3,L. Folkestad3,6, S. Cold7 and R. Eastell21Human Nutrition Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, NewcastleUniversity, Newcastle upon Tyne, UK,2Sheffield University, Department of Oncology and Metabolism, Metabolic Bone Centre, Sorby Wing, NorthernGeneral Hospital, Sheffield, UK,3Department of Endocrinology, Odense University Hospital, Odense, Denmark,4Centre for Diabetes, Academic Specialist Centre, Stockholm, Sweden,5Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Sweden,6Department of Clinical Research, University of Southern Denmark, Odense, Denmark and7Department of Oncology, Odense University Hospital, Odense, DenmarkSelenium is an essential trace element with roles in musculoskeletal health(1,2). Osteoclast inactivation is associated with selenium sup-plementation in vitro and selenium status is correlated negatively with markers of bone health(3,4). However, the impact of seleniumsupplementation on bone turnover markers (BTM) has not been studied. This study investigated the effects of selenium supplemen-tation for up to 5 years in older people on BTM including osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), carboxy-terminal collagen crosslinks and bone alkaline phosphatase.490 Danish men and women (60–74 y) were randomised to receive 0, 100, 200 or 300 μg of selenium daily as selenium-enrichedyeast. Plasma selenium concentration was measured using inductively-coupled-plasma mass spectrometry and BTMs were measuredusing an autoanalyser at baseline, 6 months and 5 years in non-fasted samples. Data were analysed by ANCOVA with polynomialcontrasts to investigate the shape of the dose-response relationships. Covariates included: age, body mass index, baseline plasma sel-enium concentration, baseline BTM, smoking, alcohol, supplement use and medication.Plasma selenium concentration increased significantly with increasing selenium supplementation at 6 months (84.1, 155.2, 212.3,258.3 ng/ml for placebo, 100, 200 and 300 μg selenium, respectively) (P < 0.001) and remained elevated at 5 years (88.2, 156.4,223.8 and 270.9 respectively) (P < 0.001). At 6 months, there was a significant linear decrease in P1NP (P = 0.036, η2 = 0.019) withincreasing selenium supplementation but this effect was not apparent at 5 years. There was no significant effect of selenium supple-mentation on any other BTM.Selenium supplementation reduced P1NP at 6 months but there were no significant effects on other BTM or after 5 years. SinceP1NP is a marker of osteoblast function, the fall in PINP with increasing selenium supplementation suggests a reduction in newbone formation 5. The impact of this change in bone turnover on bone health remains to be determined.References1. Moreno-Reyes R, et al. (2001) J Bone Miner Res 16, 1556–63.2. Zhang Z, et al. (2014) Biophys Acta 1840, 3246–3256.3. Hoeg A, et al. (2012) J Clin Endocrinol Metab 97, 4061–70.4. Beukhof CM et al. (2016) PLoS ONE 11, e0152748.5. Kuo T & Chen CH (2017) Biomark Res 5, 18Proceedings of the Nutrition Society (2021), 80 (OCE3), E110 doi:10.1017/S0029665121002330ProceedingsoftheNutritionSocietyhttps://doi.org/10.1017/S0029665121002330 Published online by Cambridge University Press

Perri, G

Hill, T

Mathers, JC

Walsh, J

Gossiel, F

Winther, K

Frolich, J

Folkestad, L

Cold, S

Eastell, R

Swepub

https://eprints.whiterose.ac.uk/195243/1/effect-of-selenium-supplementation-on-biomarkers-of-bone-turnover.pdf

Effect of selenium supplementation on biomarkers of bone turnover

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