Traditional enterprise information systems have been around for more than 40 years. They are designed to support business processes and deliver information to the people within a company who require it for their work. However, there are blind spots that these systems are unable to address. In this article, we investigate how digital twins, which are based on the technology and architecture of the Industrial Internet of Things, as well as the principles of cyber-physical systems, can be used to fill such gaps and elucidate how their application will affect the prospective relationship between internal information systems and digital twins. The insights are based on a single case study within the logistics department of an industrial company and its service provider. From the case study, properties of both system types were identified that provided a basis for comparison and stimulated discussion about their future dependencies