An extensive simulation program is used in this study to discover the best ANN model for predicting the compressive strength of concrete with respect to the percentage of mineral admixture and percentage of crystalline admixture. To accomplish this, an experimental database of 100 samples is compiled from the literature and utilized to find the best ANN architecture. The main aim of this paper was to predict the strength properties of self-healing concrete (SHC) with crystalline admixture and different mineral admixtures using an artificial neural network (ANN). The samples, 100 in Number, with different mixes, were analyzed after 28 days of curing of the samples. ANN was fed with the experimental data containing four input parameters: mineral admixture (MA), percentage of mineral admixture (PMA), Percentage of crystalline admixture (PCA), and type of exposure (TE). Correspondingly, strength (Fc) was the output parameter. The experimental data showed a good correlation with the values predicted by ANN. In conclusion, ANN could be used to accurately evaluate SHC strength characteristics