Abriel, Hugues

Reymond, Jean-Louis

English

CHIMIA

A989 CHIMIA 2022, 76, No. 12 NCCR TRaNsCuRe – exCelleNCe iN MeMbRaNe TRaNspoRT ReseaRCh 2010–2022EditorialNCCR TransCure – Excellence in Membrane Transport Researchfrom 2010 until 2022Dear Readers,This special issue of CHIMIA presents the National Center of Competence in Research (NCCR)TransCure. In 2010, the NCCR TransCure was launched as an initiative of Matthias A. Hediger(University of Bern) to “find remedies for major human diseases by studying the structure, function,basic biology and pathology of strategically important transport proteins and develop drugs thatcontrol them in the diseased states.” The project focused on solute carrier transporter (SLC) and ionchannel proteins selected for their relevance in human diseases and represented an unprecedentedinterdisciplinary effort involving three separate disciplines: transport physiology, structural biology,and chemistry, with participating groups across Switzerland.The first article by Valentina Rossetti and Hugues Abriel (University of Bern) presents theorganization and main achievements of the network. The importance of physiology, pathophysiology,and structure of transporters is the topic of the articles by Christiane Albrecht (University of Bern)and Raimund Dutzler (University of Zürich), focused on iron transport, and Dimitrios Fotiadis(University of Bern) focused on amino acid transporters (SLC7 family). Daniel Fuster (Universityof Bern and Insel Spital Bern) reports on the project dealing with the physiological and molecularfunction of the sodium/hydrogen exchanger NHA2 (SLC9B2), Bruno Stieger (University of Zürich)reviews recent progress on understanding bile acid transporters and their implication in diseases, andAndrea Volterra (University of Lausanne) reports on an approach to modulate the astrocyte-specificvesicular glutamate transporter VGLUT1 using specific nanobodies. Christine Peinelt (University ofBern) presents a project investigating the pharmacology and disease mechanisms of TRPM4, a non-selective cationic channel involved in cardiovascular disorders and cancer. Jean-Louis Reymond(University of Bern) summarizes the computational drug discovery efforts realized by his group tosupport the NCCR, and Murielle Bochud (University of Lausanne) reports on the PhenoExplorerplatform and its usage applied to the NCCR TransCure targets.Among the non-scientific objectives of the NCCR TransCure, outreach events played an importantpart in the activities. This aspect is featured in the concluding article about the motivation andimplementation of Vitaport, an original learning and artistic path led by Valentina Rossetti and Jean-Louis Reymond, which was presented in the Elfenau park in Bern in August–October 2022.We trust that this special CHIMIA issue will inform you about some of the key achievements of theNCCR TransCure. We are extremely grateful to all authors and reviewers of these articles and wishyou, dear Readers, a pleasant read.Hugues Abriel and Jean-Louis ReymondThe CHIMIA Editorial Board thanks the guest editors Prof. Hugues Abriel and Prof. Jean-Louis Reymond fororganising this special issue summarising the many activities of the NCCR TransCure, demonstrating how theobjectives of the NCCR TransCure have been admirably fulfilled.

NCCR TransCure - Excellence in Membrane Transport Research from 2010 until 2022

https://www.chimia.ch/chimia/article/download/2022_989/2022_989

NCCR TransCure - Excellence in Membrane Transport Research from 2010 until 2022

Abstract

Similar works

Full text

Available Versions

CHIMIA