The effect of low dose (7.5 mg/kg) of Aspirin on ovary tissue during implantation period in mice (NMRI)

Abstract

Background: Aspirin is a non steroidal medicine that effects on prostaglandin, follicles, ovulation and corpus luteum. The aim of this study was to evaluate the effect of low (7.5 mg/kg) dose of Aspirin on the ovarian tissue during implantation period. Materials and Methods: Females NMRI mice 6-8 weeks old were divided into control and experimental groups. These groups were rendered pseudopregnant then experimental group injected with low dose of Aspirin until 4.5th day. The mice were scarified with cervical dislocation and then the samples were obtained from the ovary in each group. Then ovarian weight and volume balance were measured and paper section stained with H&E method. Results: Our results showed that weight of ovary in control group was 3.1±0.077g and in experimental group was 3.5±0.24g (p<0.05). Volume of ovary in control group was 8.70±0.19 mm3, and in experimental group was 9.20±0.17 mm3 (p<0.05). Number of corpus luteum in control group was 6.2±0.15, and in experimental group was 12.21±0.15 (p<0.05). In experimental group vascularity of ovary had increased in comparison with control group. Conclusion: The low dose of Aspirin (7.5mg/kg) increased the rate of corpus luteum and vascularity of ovary . Low dose of aspirin had positive effect on pregnancy during implantation period