A pot experiment was conducted to evaluate the effect of grain presoaking in kinetin ( 0.1 mM), spermine (0.3 mM) and their interaction on yield components and biochemical aspects of yielded grains of wheat plants irrigated with 25% seawater . Seawater induced marked reduction in biochemical aspects of yielded grains especially carbohydrates content, nitrogenous constituents, total protein and nucleic acids contents as well as proline and organic acids (citric and keto-acids) content. Conversely, seawater stress increased phosphorus and ions (Na+, K+ and Cl-) content. Application of kinetin or spermine appeared to mitigate the effect of seawater stress on wheat yield and the biochemical aspects of yielded grains. The effect was more pronounced with kinetin + spermine treatment