As a common laboratory practice, rats are studied as biological models for understanding human physiology. Even though, with the advent of modern computer sciences, new methodologies appeared in medical sciences like simulation and optimization to simplify and improve the experimental work. With this background, a novel simulation model of the endocrine system of Sprague Dawley rats is presented. It is a simplified mathematical model composed of 3 differential equations and 8 parameters that have been determined and validated with experimental measures of plasma glucose and insulin alone by means of calculus and optimization techniques. The results presented here are a step before the development of a type I diabetic model of Sprague Dawley rats.Sociedad Argentina de Informática e Investigación Operativ
