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Life in hot carbon monoxide: The complete genome sequence of carboxydothermus hydrogenoformans Z-2901
Authors
LM Brinkac
SC Daugherty
+15 more
RJ Dodson
JA Eisen
JM Gonzalez
KM Jones
JF Kolonay
R Madupu
WC Nelson
Q Ren
FT Robb
A Scott Durkin
SA Sullivan
LJ Tallon
LE Ulrich
M Wu
IB Zhulin
Publication date
1 December 2005
Publisher
eScholarship, University of California
Abstract
We report here the sequencing and analysis of the genome of the thermophilic bacterium Carboxydothermus hydrogenoformans Z-2901. This species is a model for studies of hydrogenogens, which are diverse bacteria and archaea that grow anaerobically utilizing carbon monoxide (CO) as their sole carbon source and water as an electron acceptor, producing carbon dioxide and hydrogen as waste products. Organisms that make use of CO do so through carbon monoxide dehydrogenase complexes. Remarkably, analysis of the genome of C. hydrogenoformans reveals th e presence of at least five highly differentiated anaerobic carbon monoxide dehydrogenase complexes, which may in part explain how this species is able to grow so much more rapidly on CO than many other species. Analysis of the genome also has provided many general insights into the metabolism of this organism which should make it easier to use it as a source of biologically produced hydrogen gas. One surprising finding is the presence of many genes previously found only in sporulating species in the Firmicutes Phylum. Although this species is also a Firmicutes, it was not known to sporulate previously. Here we show that it does sporulate and because it is missing many of the genes involved in sporulation in other species, this organism may serve as a ''minimal'' model for sporulation studies. In addition, using phylogenetic profile analysis, we have identified many uncharacterized gene families found in all known sporulating Firmicutes, but not in any non-sporulating bacteria, including a sigma factor not known to be involved in sporulation previously. Copyright: ©2005 Wu et al
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Last time updated on 25/12/2021