Gambaran Histologik Aorta Kelinci Yang Diinduksi Dengan Lemak Babi Dan Diberi Ekstrak Beras Hitam

Abstract

: Dyslipidemia is an abnormal lipid metabolism, marked by the alteration of lipid fractions within the blood plasma. World Health Organization reported that dyslipidemia was associated with heart diseases in general with 4 million deaths each year. Dyslipidemia is mostly caused by unhealthy lifestyle. The change of lifestyle can be initiated by the modification of diet. Black rice (Oryza sativa L.) is a type of local rice which contains a different pigment than the regular or any other colored rice. This study aimed to identify the histological changes of rabbit aorta induced with lard and black rice extract diet. This was an experimental study with a post-test design. Subjects were three rabbits New Zealand white divided into 3 groups (A. B. And C) of 1 rabbit each. Group A was fed with standard diet (Vitamax), group B with high fat diet, meanwhile group C was fed with high fat diet added with black rice extracts. This study was carried out for 28 days, after that all the rabbits were terminated to obtain their aortas. The results showed that there were reductions of LDL and total cholesterol levels of group C. Foam cells were found in the tunica intima and tunica media in group A, B and C. However, the foam cells in group C were less than the other groups. Conclusion: Black rice diet could reduce the LDL and total cholesterol levels as well as the number of foam cells in the aorta tunica of rabbits