Andresen, Thomas Lars

Bruun, Linda Maria

Christiansen, Anders N.

Clausen, Mads Hartvig

Hansen, Anders Elias

Jølck, Rasmus Irming

Kjær, Andreas

Schaarup-Jensen, Henrik

Scherman, Per Jonas Bengtsson

Online Research Database In Technology

                       General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.  • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal   If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.     Downloaded from orbit.dtu.dk on: Dec 20, 2017Sucrose acetate isobutyrate based nanogels as liquid fiducial tissue markers withpotential use in image guided radiotherapyBruun, Linda Maria; Schaarup-Jensen, Henrik; Jølck, Rasmus Irming; Hansen, Anders Elias;Christiansen, Anders N.; Clausen, Mads Hartvig; Kjær, Andreas; Scherman, Per Jonas Bengtsson;Andresen, Thomas LarsPublication date:2014Link back to DTU OrbitCitation (APA):Bruun, L. M., Schaarup-Jensen, H., Jølck, R. I., Hansen, A. E., Christiansen, A. N., Clausen, M. H., ... Andresen,T. L. (2014). Sucrose acetate isobutyrate based nanogels as liquid fiducial tissue markers with potential use inimage guided radiotherapy. Abstract from Træf for Organisk KemiStuderende 2014, Lyngby, Denmark.SUCROSE ACETATE ISOBUTYRATE BASED NANOGELS AS LIQUID FIDUCIAL TISSUE MARKERS WITH POTENTIAL USE IN IMAGE GUIDED RADIOTHERAPY Linda M. Bruun1,2, Henrik Schaarup-Jensen1,3, Rasmus I. Jølck1,2, Anders E. Hansen1,2, Anders N. Christiansen4, Mads H. Clausen1,3, Andreas Kjær5, Per Jonas Bengtsson Scherman6 and Thomas L. Andresen1,2 1Technical University of Denmark, Center for Nanomedicine and Theranostics, 2800 Kgs. Lyngby, Denmark and 2Technical University of Denmark, Department of Micro-and Nanotechnology, 2800 Kgs. Lyngby, Denmark and 3Technical University of Denmark, Department of Chemistry, 2800 Kgs. Lyngby, Denmark and 4Technical University of Denmark, DTU Compute, Department of Applied Mathematics and Computer Science,2800 Kgs. Lyngby, Denmark. Rigshospitalet and University of Copenhagen, 5Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, 2100 Copenhagen, Denmark. 6Department of Oncology, Section of Radiotherapy, Rigshospitalet, 2100 Copenhagen, Denmark. Image-guided radiotherapy (IGRT) is a tool used to enable delivery of high radiation doses to precisely defined targets. In order to fixate the position of tumors, Radiopaque fiducial markers (RFMs) are placed within or near tumors to enhance radiation accuracy. The poster presents the development of injectable RFMs based on coated gold nanoparticles (AuNPs) encapsulated within a secondary medium of sucrose acetate isobutyrate (SAIB), EtOH and polylactide (PLA). Upon injection, the composition forms a fiducial gel-like implant. Three different AuNP coatings were tested; PEG - and PNIPAM polymers and a dithiolane functionalized SAIB derivative. The dithiolane SAIB coating was discarded due to irreversible AuNP aggregation. The PEG-AuNP-SAIB-gel provided high CT contrast in vivo; however, AuNP migration was observed over time as well as substantial in vitro burst release. The PNIPAM-AuNP-SAIB-gel provided excellent contrast and high stability in vivo, and was therefore assessed to be a suitable marker for IGRT.          

Sucrose acetate isobutyrate based nanogels as liquid fiducial tissue markers with potential use in image guided radiotherapy

http://orbit.dtu.dk/ws/files/103754758/Abstract_Poster_TOKS_2014.pdf

Sucrose acetate isobutyrate based nanogels as liquid fiducial tissue markers with potential use in image guided radiotherapy

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