THE EFFECTS OF AEROBIC AND ANAEROBIC PHYSICAL ACTIVITY ON INSULIN DOSE REDUCTION IN DIABETICS

Abstract

Kako bi spriječili hipoglikemiju i hiperglikemiju tijekom vježbanja, dijabetièari moraju prilagoditi svoju prehranu i doziranje inzulina. Cilj ovog istraživanja bio je utvrditi da li i u kojoj mjeri aerobna i anaerobna tjelesna aktivnost utječe na razinu glukoze u krvi i potreban broj jedinica inzulina kod pacijenata oboljelih od dijabetesa tipa 1 koji prethodno nisu redovito vježbali. Trideset ispitanika (prosječne dobi 26,8±8,6; starosti 16-49 godina), 17 ženskih i 13 muških, pohaðali su jedan mjesec treninga koji se sastojao ili od dominantno aerobnog tipa treniranja (34% ispitanika) ili od anaerobnog tipa treniranja (20% ispitanika) ili mješovitog (46% ispitanika. Svi ispitanici bolovali su od dijabetesa tipa 1 i primali su inzulinsku terapiju. Vrijednosti HbA1c, prosječne visine glukoze u krvi i dnevnog broja jedinica inzulina bile su zabilježene prije i poslije razdoblja treniranja. Rezultati Student t-testa za nezavisne uzorke pokazali su da su srednje vrijednosti HbA1c značajno smanjene (7,95±0,73 vs. 7,74±0,56%, p < 0,001). Takoðer, smanjenje dnevne potrošnje inzulina bilo je statistièki znaèajno (52,1±6,0 jedinice inzulina vs 42,68±5,2 jedinica, p < 0,001), kao i GUK (8,25±0,78 vs 7,84±0,68 mmol/L, p < 0,001). Nije bilo razlika izmeðu aerobnog, anaerobnog i mješovitog tipa treninga, ali zbog problema malog uzorka ne možemo tvrditi da one ne postoje (ANOVA rezultati: Wilks Lambda = 0715 , F (6,22) = 0.679, p = 0.674). Iako nismo bili u mogućnosti utvrditi odnos izmeðu vrste aktivnosti i smanjenja promatranih vrijednosti, uspjeli smo potvrditi smanjenje u odnosu s volumenom aktivnosti. Ne-parametarski korelacijski test potvrdio je statistički značajne korelacije izmeðu volumena dnevne tjelesne aktivnosti u minutama i smanjenje HbA1c (Spearman R= 0,57); prosječnog smanjenja razine glukoze u krvi (Spearman R = 0,44) i dnevnog broja jedinica inzulina koja se uzima (Spearman R = 0,54).To prevent hypo and hyperglycemia during exercise, diabetics need to adjust their nutrition and insulin dosage. The aim of this study was to determine whether and how physical activity affects the blood glucose levels and the required amount of insulin in previously sedentary patients suffering from type 1 diabetes. Thirty subjects (mean age 26,8±8,6; range 16-49 years), 17 female and 13 male, underwent the one month training procedure consisting of either dominantly aerobic type of training (34% of subjects) anaerobic type of training (20% of subjects) or mixed (46% of subjects). All of the subjects suffered from diabetes mellitus, type 1 and were receiving insulin therapy. The values of HbA1c, the mean blood glucose concentration and the number of insulin units received daily were recorded before and after the exercise intervention. The monitored parameters were measured once again after the intervention. The results of the Student t-test for independent samples showed that the mean values of HbA1c decreased significantly (7,95±0,73 vs. 7,74±0,56%; p<0,001). Similarly, the decrease in the daily insulin unit consumption was also statistically significant (52,1±6,0 Ins units vs. 42,68±5,2 units; p<0,001), and mean blood glucose as well (8,25±0,78 vs. 7,84±0,68 mmol/L; p < 0,001). No differences were found but as for the problem of the small number of subjects in each group we could not claim that those do not exist (ANOVA results: Wilks Lambda = 0,715, F (6,22) = 0,679; p = 0,674). Even though we were unable to determine the relation between the type of the activity and the decrease of the monitored parameters, we did manage to confirm the relation of those with the activity volume. Nonparametric correlation test confirmed statistically significant correlations between the volume of the daily physical activity in minutes and the decrease in HbA1c (Spearman R= 0,57); mean blood glucose decrease (Spearman R= 0,44) and the daily insulin units used (Spearman R= 0,54

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