Conditioning Regimens in Allogeneic Hematopoietic Stem Cell Transplantation

Abstract

Conditioning plays a central role in allogeneic hematopoietic stem cell transplantation (HSCT). The aim of the conditioning regimen in allogeneic HSCT is to prepare the patient for its transplantation. Conditioning regimen is given with three main objectives: ‘creation of space’, ‘immunosuppression’ and ‘disease eradication’. Optimal conditioning regimen will eradicate the disease, enable engraftment, and cause little toxicity for the patient. Errors in its application may have serious or even fatal consequences. Then, conditioning regimens should be carefully applied in allogeneic HSCT