Eosinopenia sebagai Penanda Diagnosis Sepsis

Abstract

Sepsis adalah salah satu penyebab tersering morbiditas dan mortalitas di intensive care unit (ICU) dan merupakan masalah kesehatan besar dengan insidens yang meningkat. Salah satu tata laksana sepsis yang sangat penting adalah terapi antimikroba. Penegakan diagnosis sepsis yang kurang cepat dan tepat menyebabkan peningkatan mortalitas atau pemberian antimikroba yang tidak tepat. Untuk membantu diagnosis sepsis sering digunakan penanda diagnosis seperti C-reactive protein ( CRP ) dan prokalsitonin, namun mahal dan lama. Eosinopenia telah lama diketahui merupakan respon terhadap infeksi. Penelitian menunjukkan kaitan antara hitung eosinofil yang rendah dengan infeksi bakterial pada pasien kritis di ICU. Eosinopenia dapat digunakan sebagai penanda diagnosis sepsis alternatif khususnya di negara berkembang seperti Indonesia. Selain itu, eosinopenia dapat digunakan sebagai prediktor mortalitas pasien sepsis di ICU.Sepsis is one of the most common causes of morbidity and mortality in the intensive care unit (ICU) and a major health care problem with increasing incidence. One of the most crucial steps in sepsis management is antimicrobial therapy. Inaccurate and late diagnosis of sepsis would lead to increased mortality or inappropriate use of antimicrobial agents. To facilitate early and accurate diagnosis of sepsis, biomarkers such as c-reactive protein (CRP) and procalcitonin are frequently used, but are expensive and need considerable time. Eosinopenia is already known as a response to infection. Recent studies have shown that low eosinophil count is associated with bacterial infection in critically ill patients admitted to ICU. Due to its good reliability, rapid, easy and inexpensive measurement, eosinopenia may be used as an alternative sepsis biomarker in developing country such as Indonesia. Eosinopenia can also be used as a predictor of mortality for sepsis patients in ICU