Emulsion and Ultrasonication in the Nanoencapsulation of Ibuprophen Coated with Polyblend of Poly(lactic Acid) and Poly (ε-Caprolactone)

Abstract

Polyblend of poly(lactic acid) (PLA) and poly(ε-caprolactone)(PCL) as coating of ibuprophen has been prepared. The encapsulation of ibuprophen in this study was carried out by emulsification and ultrasonication technique. The PLA used was synthesized with an average molecule weight (Mv) 9463 g/mol. Nanocapsules obtained were ranged between 480 to 950 nm. The optimum sonication time in the formation of nanocapsules was 60 minute. The efficiency and the size of nanocapsules increased with the increasing of sonication time. The nanocapsules efficiency at sonication time 30, 45, and 60 minutes were 4.514, 9.724, and 5.987 % respectively