The research was conducted to determine the perception of peoples with HIV AIDS (PLWHA) on the role of peer support group (KDS) and the implications of these perceptions on the implementation of antiretroviral therapy (ARV). This study used a qualitative approach with case study method to PLWHA members of KDS Semarang Plus. Determination of the subjects in a purposive way and obtained 15 subjects (4 housewife, a transvestite, a son, and 9 addict who has or had undergone antiretroviral therapy). Data were collected through in-depth interviews. The results showed all subjects had positive perceptions of the role of peer support groups, and peer support groups have a role for them to obediently carry out the ARV therapy. Most subjects stated that their self-confidence, and susceptibility of disease is another factor that determines the implementation of ARV therapy. The implications of the subject’s perception of the status of antiretroviral therapy were 13 subjects dutifully implement ARV therapy and 2 subjects who had broken up antiretroviral therapy, have a desire to resume antiretroviral therapy and have the confidence to carry it out obediently