Kalia, Manu

Ligtenstein, S.L.B.

Meijer, Hil G.E.

van Putten, Michel J.A.M.

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A neural mass model for the EEG in ischemia

University of Twente Research Information

A neural mass model for the EEG in ischemiaManu Kalia1, Sophie L.B. Ligtenstein1,2, Hil G.E. Meijer1 and Michel J.A.M. van Putten21 Department of Applied Mathematics, University of Twente 2Department of Clinical Neurophysiology, University of TwenteIntroduction EEG during carotid artery clampingµV2/Hz Hz• Clinical test checking the blood flow by occlusion of carotid artery on one hemi-sphere. • The EEG shows a shift from alpha to delta rhythms and a return.• The other hemisphere shows normal EEG rhythm.Conclusion & Open QuestionsIon-based Firing Rate FunctionFiring rate computed for single neuron given reversal potentials and external input via a lookup table. For a heterogeneous population we convolute with a Gaussian kernel.Ion Dynamics of a Neural Mass Ischemia yields gradual synaptic arrestResearch Questions:• Can we lift insights of single-cell ion dynamics to neural mass models representing EEG?• What is the mechanism behind slowing?Novel Neural Mass model in terms of ion dynamics• Most neural mass models describes the average (synaptic) activity.• Instead we keep all ion species, average the fast gating variables and compute the resulting membrane potential for the firing rate.• The Sodium-Potassium-Atpase (NKA-pump) is crucial for maintaining the neuronal membrane potential, but consumes lots of ATP.• During a stroke, the pump no longer has energy. Then a neuron will gradually depolarize, then show a burst  of action potentials (wave of death) before entering permanent depolarization block (Kalia 2021).E (mV)Time (min)Transient energy blockNeuronAstrocyteModel Components(A) Active and passive ion trans-porters for Na+, K+, Cl-, Ca2+. (B) Activity leads synaptic inputs and used for EEG proxy.(C) Connectivity involves thalamocortical loop.DFG RU-2795Synapsen unter StressReference: Ion dynamics at the energy-deprived tripartite synapse. M. Kalia, H.G.E. Meijer, S.A. van Gils, M.J.A.M. van Putten and C.R. Rose, PLoS Comp Bio (2021)• Higher ATP demand of NKA-pump relative to glutamate recycling leads to synaptic arrest before cell swelling and EEG slowing.• Excitatory thalamic input controls rhythm, weak relay-interneuron strength leads to burst-suppression upon energy deprivation.• Physiological mechanism of slower glutamate cycle via adenosine?• Extend modelling to energy demand signalling with neurovascular structures and buffering via astrocytes.

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https://ris.utwente.nl/ws/files/289318670/LorentzPoster_BBM_HGE.pdf

A neural mass model for the EEG in ischemia

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University of Twente Research Information