The Ischemic heart disease constitutes the main cause of mortality in most of the industrialized countries. The influence of the sex in clinicalresult and in the answer to the treatment of the patients with acute coronary syndrome is not very certain.The present work is intended to describe the differences by sex in the patients with acute coronary syndrome without ST segment elevationadmitted in the Intensive Coronary Care Unit at the Cardiology and Cardiovascular Surgery Institute.A retrospective, descriptive study was carried out. It included 495 patients that entered in the Intensive Coronary Care Unit at the Cardiologyand Cardiovascular Surgery Institute of Cuba with diagnosis of acute coronary syndrome without ST segment elevation, in the periodfrom January 1st,2005 to December 31st, 2008. With the objective of determinate the differences between men and women with acute CoronarySyndromes without elevation of the segment ST. The demographic characteristics were extracted, the definitive diagnosis at the momentof discharge, the angiographic characteristic of the subjected patients, the need for revascularization and their immediate results. Thebiggest presence of clinical events was determined to short and medium term.The sixth decade of the life, the masculine sex and the white race were the most affected by acute coronary syndrome without ST segmentelevation. The tobacco consumption was prevalent in women. The unstable angina was presented with a higher incidence to that reportedwithout differences in relation to the sex. The major clinical events (death, infarction, recurrent angina) went scarce to the month and the 180days without differences between men and women.Significant differences existed in the behavior of the acute coronary syndrome without ST segment elevation among the sexes, fundamentallyin the prevalence of the main risk factors and the distribution of the lesions in the coronary tree. Significant differences didn't exist whenanalyzing the results of the revascularization and the long term follow u