Peh, SC

Poppema, S

van Imhoff, GW

van Spronsen, DJ

Vrints, LW

Identification of patients with Hodgkin's lymphoma who are primary refractory to chemotherapy will have great impact on treatment planning. Several studies have indicated that up-regulation of the bcl-2 protooncogene expression in non-Hodgkin's lymphoma can cause resistance to chemotherapeutic drugs, For this reason we investigated the relationship between expression of bcl-2, the pro-apoptotic protein Bax and MIB-1 with clinical drug-resistance in Hodgkin's lymphoma Methods and results: Seven patients with nodular sclerosis Hodgkin's lymphoma under 40 years of age, who failed to achieve complete remission upon primary chemotherapy and 10 matched patients who did achieve complete response were selected from the Eindhoven Cancer Registry Tissue sections from both groups of patients were stained for bcl-2, Bax and MIB-1, In the non-responding patients Reed-Sternberg cells expressed bcl-2 more frequently using a cut-off point ofConclusion: A high percentage of Reed-Sternberg cells expressing bcl-2 protein and a low expression of bcl-2 protein in the surrounding lymphocytes is associated with treatment-failure, and subsequent poor survival in young patients with nodular sclerosing Hodgkin's lymphoma. These results need further validation in larger studies.</p

Dissertations of the University of Groningen

Clinical drug-resistant nodular sclerosing Hodgkin's lymphoma is associated with decreased bcl-2 expression in the surrounding lymphocytes and with increased bcl-2 expression in the Reed-Sternberg cells

Clinical drug-resistant nodular sclerosing Hodgkin's lymphoma is associated with decreased bcl-2 expression in the surrounding lymphocytes and with increased bcl-2 expression in the Reed-Sternberg cells

Abstract

Similar works

Full text

Available Versions

Dissertations of the University of Groningen